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DTSTART;VALUE=DATE:20241205
DTEND;VALUE=DATE:20241206
DTSTAMP:20241211T120443Z
CREATED:20241205T114235Z
LAST-MODIFIED:20241211T120443Z
UID:117881-1733356800-1733443199@www.a3veen.nl
SUMMARY:A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors - publication
DESCRIPTION:In 2021\, a highly pathogenic influenza H5N1 clade 2.3.4.4b virus was detected in North America that is capable of infecting a diversity of avian species\, marine mammals\, and humans and in 2024\, clade 2.3.4.4b virus spread widely in dairy cattle in the US\, causing a few mild human cases\, but retaining specificity for avian receptors. \nHistorically\, this virus has caused up to 30% fatality in humans\, so Lin et al. performed a genetic and structural analysis of the mutations necessary to fully switch host receptor recognition. A single glutamine to leucine mutation at residue 226 of the virus hemagglutinin was sufficient to enact the change from avian to human specificity. In nature\, the occurrence of this single mutation could be an indicator of human pandemic risk. The results are publiced in the report ‘A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors‘. \nLinks:\nVogelgriepvirus maar één mutatie verwijderd van een echte ‘mensengriep’ \nAgenda – Vogelgriep uitbraak 2021-2024 / Bird flu
URL:https://www.a3veen.nl/event/a-single-mutation-in-bovine-influenza-h5n1-hemagglutinin-switches-specificity-to-human-receptors-publication/
CATEGORIES:Medisch
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